解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The 2018 summit and flank eruption of Kīlauea Volcano was one of the largest volcanic events in Hawai'i in 200 years. Data suggest that a backup in the magma plumbing system at the long-lived Pu'u 'Ō'ō eruption site caused widespread pressurization in the volcano, driving magma into the lower flank. The eruption evolv...
journal_title:Nature communications
pub_type: 杂志文章,评审
doi:10.1038/s41467-020-19190-1
更新日期:2020-11-06 00:00:00
abstract::Recently, stretchable electronics combined with wireless technology have been crucial for realizing efficient human-machine interaction. Here, we demonstrate highly stretchable transparent wireless electronics composed of Ag nanofibers coils and functional electronic components for power transfer and information commu...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19367-8
更新日期:2020-11-06 00:00:00
abstract::Plasmodium parasites possess a translocon that exports parasite proteins into the infected erythrocyte. Although the translocon components are also expressed during the mosquito and liver stage of infection, their function remains unexplored. Here, using a combination of genetic and chemical assays, we show that the t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19492-4
更新日期:2020-11-06 00:00:00
abstract::Synthetic polymers are indispensable in many different applications, but there is a growing need for green processes and natural surfactants for emulsion polymerization. The use of solid particles to stabilize Pickering emulsions is a particularly attractive avenue, but oxygen sensitivity has remained a formidable cha...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19407-3
更新日期:2020-11-05 00:00:00
abstract::Rapid and accurate clinical diagnosis remains challenging. A component of diagnosis tool development is the design of effective classification models with Mass spectrometry (MS) data. Some Machine Learning approaches have been investigated but these models require time-consuming preprocessing steps to remove artifacts...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19354-z
更新日期:2020-11-05 00:00:00
abstract::Understanding the conformational sampling of translation-arrested ribosome nascent chain complexes is key to understand co-translational folding. Up to now, coupling of cysteine oxidation, disulfide bond formation and structure formation in nascent chains has remained elusive. Here, we investigate the eye-lens protein...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19372-x
更新日期:2020-11-04 00:00:00
abstract::We present Biomedisa, a free and easy-to-use open-source online platform developed for semi-automatic segmentation of large volumetric images. The segmentation is based on a smart interpolation of sparsely pre-segmented slices taking into account the complete underlying image data. Biomedisa is particularly valuable w...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19303-w
更新日期:2020-11-04 00:00:00
abstract::Phase separation of specific biomolecules into liquid droplet-like condensates is a key mechanism to form membrane-less organelles, which spatio-temporally organize diverse biochemical processes in cells. To investigate the working principles of these biomolecular condensates as dynamic reaction centers, precise contr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19391-8
更新日期:2020-11-03 00:00:00
abstract::Cas9/gRNA-mediated gene-drive systems have advanced development of genetic technologies for controlling vector-borne pathogen transmission. These technologies include population suppression approaches, genetic analogs of insecticidal techniques that reduce the number of insect vectors, and population modification (rep...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19426-0
更新日期:2020-11-03 00:00:00
abstract::Covalent organic frameworks (COFs) have served as a family of porous crystalline molecules for various promising applications. However, controllable synthesis of COFs with uniform morphology is paramount yet still remains quite challenging. Herein, we report self-templated synthesis of uniform and unique hollow sphere...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18844-4
更新日期:2020-11-03 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Nature communications
pub_type: 已发布勘误
doi:10.1038/s41467-020-19626-8
更新日期:2020-11-03 00:00:00
abstract::MAVS and MITA are essential adaptor proteins mediating innate antiviral immune responses against RNA and DNA viruses, respectively. Here we show that RNF115 plays dual roles in response to RNA or DNA virus infections by catalyzing distinct types of ubiquitination of MAVS and MITA at different phases of viral infection...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19318-3
更新日期:2020-11-02 00:00:00
abstract::Cyclin D1 is one of the most important oncoproteins that drives cancer cell proliferation and associates with tamoxifen resistance in breast cancer. Here, we identify a lncRNA, DILA1, which interacts with Cyclin D1 and is overexpressed in tamoxifen-resistant breast cancer cells. Mechanistically, DILA1 inhibits the pho...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19349-w
更新日期:2020-11-02 00:00:00
abstract::Conventional epitaxy of semiconductor films requires a compatible single crystalline substrate and precisely controlled growth conditions, which limit the price competitiveness and versatility of the process. We demonstrate substrate-tolerant nano-heteroepitaxy (NHE) of high-quality formamidinium-lead-tri-iodide (FAPb...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19237-3
更新日期:2020-11-02 00:00:00
abstract::Single-cell RNA-sequencing (scRNA-Seq) is a compelling approach to directly and simultaneously measure cellular composition and state, which can otherwise only be estimated by applying deconvolution methods to bulk RNA-Seq estimates. However, it has not yet become a widely used tool in population-scale analyses, due t...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19365-w
更新日期:2020-10-30 00:00:00
abstract::Quasi-two-dimensional perovskites have emerged as a new material platform for optoelectronics on account of its intrinsic stability. A major bottleneck to device performance is the high charge injection barrier caused by organic molecular layers on its basal plane, thus the best performing device currently relies on e...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19331-6
更新日期:2020-10-30 00:00:00
abstract::Myelinating oligodendrocytes enable fast propagation of action potentials along the ensheathed axons. In addition, oligodendrocytes play diverse non-canonical roles including axonal metabolic support and activity-dependent myelination. An open question remains whether myelination also contributes to information proces...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19152-7
更新日期:2020-10-30 00:00:00
abstract::Elemental phosphorus is attracting growing interest across fundamental and applied fields of research. However, atomistic simulations of phosphorus have remained an outstanding challenge. Here, we show that a universally applicable force field for phosphorus can be created by machine learning (ML) from a suitably chos...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19168-z
更新日期:2020-10-29 00:00:00
abstract::Eicosapentaenoic acid (EPA), an omega-3 fatty acid, has been widely used to prevent cardiovascular disease (CVD) and treat brain diseases alone or in combination with docosahexaenoic acid (DHA). However, the impact of EPA and DHA supplementation on normal cognitive function and the molecular targets of EPA and DHA are...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19255-1
更新日期:2020-10-29 00:00:00
abstract::Pterosaurs, the first vertebrates to evolve active flight, lived between 210 and 66 million years ago. They were important components of Mesozoic ecosystems, and reconstructing pterosaur diets is vital for understanding their origins, their roles within Mesozoic food webs and the impact of other flying vertebrates (i....
journal_title:Nature communications
pub_type: 历史文章,杂志文章
doi:10.1038/s41467-020-19022-2
更新日期:2020-10-28 00:00:00
abstract::The expansion of the white adipose tissue (WAT) in obesity goes along with increased mechanical, metabolic and inflammatory stress. How adipocytes resist this stress is still poorly understood. Both in human and mouse adipocytes, the transcriptional co-activators YAP/TAZ and YAP/TAZ target genes become activated durin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19229-3
更新日期:2020-10-28 00:00:00
abstract::Novel atherosclerosis models are needed to guide clinical therapy. Here, we report an in vitro model of early atherosclerosis by fabricating and perfusing multi-layer arteriole-scale human tissue-engineered blood vessels (TEBVs) by plastic compression. TEBVs maintain mechanical strength, vasoactivity, and nitric oxide...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19197-8
更新日期:2020-10-27 00:00:00
abstract::The novel coronavirus disease 2019 (COVID-19) was first reported in Wuhan, China, where the initial wave of intense community transmissions was cut short by interventions. Using multiple data sources, here we estimate the disease burden and clinical severity by age of COVID-19 in Wuhan from December 1, 2019 to March 3...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19238-2
更新日期:2020-10-27 00:00:00
abstract::Biomarkers are needed for predicting the effectiveness of disease modifying antirheumatic drugs (DMARDs). Here, using functional lipid mediator profiling and deeply phenotyped patients with early rheumatoid arthritis (RA), we observe that peripheral blood specialized pro-resolving mediator (SPM) concentrations are li...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19176-z
更新日期:2020-10-27 00:00:00
abstract::Methanol is a biotechnologically promising substitute for food and feed substrates since it can be produced renewably from electricity, water and CO2. Although progress has been made towards establishing Escherichia coli as a platform organism for methanol conversion via the energy efficient ribulose monophosphate (Ru...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19235-5
更新日期:2020-10-26 00:00:00
abstract::Homeowners around the world elevate houses to manage flood risks. Deciding how high to elevate a house poses a nontrivial decision problem. The U.S. Federal Emergency Management Agency (FEMA) recommends elevating existing houses to the Base Flood Elevation (the elevation of the 100-year flood) plus a freeboard. This r...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19188-9
更新日期:2020-10-26 00:00:00
abstract::Numerous examples of biosynthetic gene clusters (BGCs), including for compounds of agricultural and medicinal importance, have now been discovered in plant genomes. However, little is known about how these complex traits are assembled and diversified. Here, we examine a large number of variants within and between spec...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19153-6
更新日期:2020-10-23 00:00:00
abstract::Human C-terminal binding protein (CtBP)-interacting protein (CtIP) is a central regulator to initiate DNA end resection and homologous recombination (HR). Several studies have shown that post-translational modifications control the activity or expression of CtIP. However, it remains unclear whether and how cells restr...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19202-0
更新日期:2020-10-23 00:00:00
abstract::Bloch electrons lacking inversion symmetry exhibit orbital magnetic moments owing to the rotation around their center of mass; this moment induces a valley splitting in a magnetic field. For the graphene/h-BN moiré superlattice, inversion symmetry is broken by the h-BN. The superlattice potential generates a series of...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19043-x
更新日期:2020-10-23 00:00:00
abstract::Designing highly durable and active electrocatalysts applied in polymer electrolyte membrane (PEM) electrolyzer for the oxygen evolution reaction remains a grand challenge due to the high dissolution of catalysts in acidic electrolyte. Hindering formation of oxygen vacancies by tuning the electronic structure of catal...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19212-y
更新日期:2020-10-23 00:00:00
abstract::Arterial networks enlarge in response to increase in tissue metabolism to facilitate flow and nutrient delivery. Typically, the transition of a growing artery with a small diameter into a large caliber artery with a sizeable diameter occurs upon the blood flow driven change in number and shape of endothelial cells lin...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19008-0
更新日期:2020-10-21 00:00:00
abstract::5-Fluorouracil (5-FU) remains the first-line treatment for colorectal cancer (CRC). Although 5-FU initially de-bulks the tumor mass, recurrence after chemotherapy is the barrier to effective clinical outcomes for CRC patients. Here, we demonstrate that p53 promotes WNT3 transcription, leading to activation of the WNT/...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19173-2
更新日期:2020-10-21 00:00:00
abstract::MicroRNAs (miRNAs) are endogenous small RNAs of ∼21 nt that regulate multiple biological pathways in multicellular organisms. They derive from longer transcripts that harbor an imperfect stem-loop structure. In plants, the ribonuclease type III DICER-LIKE1 assisted by accessory proteins cleaves the precursor to releas...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19129-6
更新日期:2020-10-21 00:00:00
abstract::Much of the world's Li deposits occurs as basinal brines in magmatic orogens, particularly in continental volcanic arcs. However, the exact origin of Li enrichment in arc magmatic systems is not clear. Here, we show that, globally, primitive arc magmas have Li contents and Li/Y ratios similar to mid-ocean ridge basalt...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19106-z
更新日期:2020-10-20 00:00:00
abstract::Extrachromosomal telomeric circles are commonly invoked as important players in telomere maintenance, but their origin has remained elusive. Using electron microscopy analysis on purified telomeres we show that, apart from known structures, telomeric repeats accumulate internal loops (i-loops) that occur in the proxim...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19139-4
更新日期:2020-10-20 00:00:00
abstract::Regulation of protein N-glycosylation is essential in human cells. However, large-scale, accurate, and site-specific quantification of glycosylation is still technically challenging. We here introduce SugarQuant, an integrated mass spectrometry-based pipeline comprising protein aggregation capture (PAC)-based sample p...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19052-w
更新日期:2020-10-19 00:00:00
abstract::Despite the fundamental importance of efficient and selective synthesis of widely useful alkylarenes, the direct catalytic C(sp2)-H alkylation of unactivated arenes with a readily available alkyl halide remains elusive. Here, we report the catalytic C(sp2)-H alkylation reactions of unactivated arenes with alkyl bromid...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19038-8
更新日期:2020-10-19 00:00:00
abstract::16p11.2 and 22q11.2 Copy Number Variants (CNVs) confer high risk for Autism Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Deficit-Hyperactivity-Disorder (ADHD), but their impact on functional connectivity (FC) remains unclear. Here we report an analysis of resting-state FC using magnetic resonance imaging...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-18997-2
更新日期:2020-10-19 00:00:00
abstract::The modern energy economy and environmental infrastructure rely on the flow of fluids through fractures in rock. Yet this flow cannot be imaged directly because rocks are opaque to most probes. Here we apply chattering dust, or chemically reactive grains of sucrose containing pockets of pressurized carbon dioxide, to ...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19087-z
更新日期:2020-10-19 00:00:00
abstract::Development of sensitive local probes of magnon dynamics is essential to further understand the physical processes that govern magnon generation, propagation, scattering, and relaxation. Quantum spin sensors like the NV center in diamond have long spin lifetimes and their relaxation can be used to sense magnetic field...
journal_title:Nature communications
pub_type: 杂志文章
doi:10.1038/s41467-020-19121-0
更新日期:2020-10-16 00:00:00